X-Men Origins: Wolverine (2009)
Wade Wilson, also known as Deadpool is a wisecracking mercenary with lethal swordsmanship skill and athleticism.
Deadpool (2016), Deadpool: The Second Coming (2018), X-Force (2018)
Wade was diagnosed with inoperable brain cancer, and signed up to join the Weapon X program which gave him a healing factor similar to Wolverine. It resulted in his mind being in a constant state of disarray; the cancer cells are repeatedly destroyed but regenerated in a never ending loop.